healthFriday, November 6, 2026 at 09:50 PM
Emory 10-Protein Panel Reaches 98% Accuracy for ALS, Outperforming NfL in Plasma Cohort of 792
The Emory 10-protein panel delivered 98% balanced accuracy for ALS versus controls and outperformed NfL by capturing multiple disease processes. Observational data from 792 plasma samples support earlier triage but require mimic-condition validation before clinical adoption. Evidence remains at the discovery stage pending prospective diagnostic accuracy studies.
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91.0% accuracy0 views
Next steps require testing against ALS mimics such as multifocal motor neuropathy and cervical spondylotic myelopathy. Without those data the signature remains a screening rather than confirmatory tool. Ongoing multi-center validation will determine whether the 98% figure holds when prevalence and comorbidity profiles shift.
Sources (2)
- [1]Primary Source(https://doi.org/10.1038/s41467-026-78766-5)
- [2]Supporting Source(https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00179-2/fulltext)