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Phase 1 QUILT-106 Trial Tests Allogeneic CD19-CAR NK Cells in Relapsed B-Cell Lymphoma

Phase 1 QUILT-106 Trial Tests Allogeneic CD19-CAR NK Cells in Relapsed B-Cell Lymphoma

QUILT-106 evaluates whether a scalable allogeneic CAR-NK product can bypass patient-specific manufacturing for CD19-positive lymphomas. Limited phase 1 data suggest acceptable tolerability but underscore the need for larger trials to define durable response rates and cost-effectiveness against autologous CAR-T benchmarks.

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The trial imports a single master cell-bank-derived NK line engineered with a CD19 CAR and tests it alone or combined with rituximab. Primary endpoints are safety and dose-limiting toxicity; secondary signals include overall response rate. Early observations show heterogeneous results, with some patients achieving rapid complete remission while others show no response, consistent with phase 1 variability in small cohorts.

Sources (2)

  • [1]
    Primary Source(https://medicalxpress.com/news/2026-11-south-african-trial-shelf-killer.html)
  • [2]
    Supporting Source(https://www.nejm.org/doi/full/10.1056/NEJMoa2300051)