Colossal Biosciences has developed a 3D-printed oval lattice coated with a silicone-based membrane that permits oxygen exchange, enabling transferred chicken egg contents to continue development to hatching as reported in their May 2026 announcement. The work builds directly on prior avian ex utero systems, including Katsuya Obara's 2024 transparent film method at University of Tsukuba and the 1998 quail embryo transfers documented in Japanese developmental biology records, with Colossal's membrane cited as reducing supplemental oxygen needs. This advance aligns with Colossal's Exo Dev team's parallel marsupial artificial womb research and their $800 million de-extinction pipeline targeting moa genome edits from bone-derived DNA, extending synthetic biology applications to at-risk avian conservation per company statements.