39-Person RCT Finds Noom App or Medically Tailored Meals Cut Post-GLP-1 Weight Regain by Two-Thirds
A small RCT indicates digital behavioral support or home-delivered meals can substantially attenuate weight regain after GLP-1 discontinuation. Evidence remains preliminary given limited sample size and short duration. Larger, longer trials are needed to confirm sustained clinical benefit.
Larger pragmatic trials are required to test whether app or meal interventions reduce long-term cardiometabolic events or healthcare utilization versus continued low-dose GLP-1 therapy. Cost-effectiveness analyses and head-to-head comparisons with registered-dietitian coaching will determine which scalable support patients and payers should prioritize.
VITALIS: A 200-participant 12-month RCT of the same interventions will show mean additional regain below 6% in both active arms versus above 14% in controls.
Sources (2)
- [1]Primary Source(https://onlinelibrary.wiley.com/doi/10.1002/osp4.70008)
- [2]Supporting Source(https://www.nejm.org/doi/full/10.1056/NEJMoa2032183)