The Gladstone Institutes study, published in Cell, introduces a neuron-specific ZsGreen tracer in mice that tracks endogenous brain waste rather than flooding the system with exogenous dyes. This experimental approach, distinct from prior observational glymphatic work, reveals a 'nearest exit' drainage model where forebrain proteins route dorsally while striatal debris exits basally via dura, skull, and nasal routes—challenging the cervical lymph node emphasis from traditional CSF injections. As an animal model study without reported human validation or randomization, its sample size remains modest and findings carry translational limits; no conflicts of interest were declared by the Gladstone team. Synthesizing this with Iliff et al.'s 2012 Science paper on aquaporin-4-mediated interstitial fluid flow (animal tracer experiments, n=~50 mice across cohorts) and the 2015 Louveau et al. Nature report on meningeal lymphatics (observational mouse and human dural imaging), the new data suggest prior methods overestimated bulk CSF routes while underplaying immune cell interactions at border sites. Alzheimer's disruption appears regionally selective, potentially scrambling ZIP-code drainage before global protein buildup, a pattern overlooked in broad anti-amyloid trials. This mechanistic insight prioritizes early, location-specific prevention over systemic clearance boosters.