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healthSunday, November 1, 2026 at 11:31 PM
LATE-MT Trial: Thrombectomy 24-72 Hours Post-Stroke Raises Independent Living to 49% but Adds 4.8% Hemorrhage Risk

LATE-MT Trial: Thrombectomy 24-72 Hours Post-Stroke Raises Independent Living to 49% but Adds 4.8% Hemorrhage Risk

LATE-MT demonstrates thrombectomy can improve outcomes beyond 24 hours in selected patients but increases serious bleeding. Evidence remains single-region and requires replication. Future studies must address generalizability and optimal imaging thresholds.

Risk-benefit trade-offs require careful patient selection via advanced imaging; routine expansion risks excess harm without standardized protocols. Next steps include ongoing international trials and planned individual-patient meta-analyses to refine selection criteria before guideline updates.

⚡ Prediction

AHA guideline committee: Expanded 72-hour thrombectomy recommendation issued by Q4 2027 if two additional multinational RCTs confirm net benefit above 40% absolute gain.

Sources (2)

  • [1]
    Primary Source(https://www.nejm.org/doi/full/10.1056/NEJMoa2609362)
  • [2]
    Supporting Source(https://www.nejm.org/doi/full/10.1056/NEJMoa1713973)