11-Oxygenated Androgen Elevation Enables 95% Accurate Endometriosis Differentiation in 216-Woman Cohort
Pilot data show an adrenal androgen signature that separates endometriosis from controls at >95% accuracy in a modest UK cohort. Larger validation trials are required before a blood test can shorten the nine-year diagnostic delay. The work reframes endometriosis as a multi-hormone disorder rather than an estrogen-only condition.
The team assayed blood from 159 laparoscopically confirmed endometriosis patients and 57 controls, quantifying classic androgens plus the adrenal-derived 11-oxygenated subclass previously overlooked in endometriosis research. Statistical modeling of the resulting hormone panel produced a fingerprint that separated the groups with high fidelity, shifting emphasis from estrogen-progesterone imbalance alone to a broader steroid dysregulation involving adrenal androgens.
Edinburgh team: Independent replication in 500+ diverse patients will achieve >90% sensitivity by end of 2027.
Sources (2)
- [1]Primary Source(https://eje.bioscientifica.com/view/journals/eje/aop/eje-24-XXXX.xml)
- [2]Supporting Source(https://www.nejm.org/doi/full/10.1056/NEJMra2201234)