Tissue-resident memory T cells sustain psoriasis recurrence at prior sites; early biologic response linked to epigenetic reset in Duvetorp cohort

Psoriasis recurrence is driven by stable TRM cells and epigenetic memory that biologics can reset more effectively in early, rapid responders. Obesity impairs this reset via chronic inflammatory amplification. The findings align with broader autoimmune patterns where durable remission requires memory erasure, not perpetual suppression.