Transient mRNA Activation of Myc and Cyclin T1 Boosts Ejection Fraction 10% in Mouse Infarct Model
A mouse interventional study demonstrates that short-lived mRNA activation of two cell-cycle regulators can induce cardiomyocyte proliferation and measurably improve pump function after infarction. Gains are durable to 12 weeks and appear spatially restricted, yet the work remains confined to rodents and lacks long-term tumorigenicity or arrhythmia data. Human translation will require larger-mammal safety studies and dose-escalation trials.
University of Cambridge investigators injected mRNA encoding Myc and Cyclin T1 into infarcted mouse hearts immediately after coronary ligation. Echocardiography quantified systolic function; proliferation was tracked by EdU incorporation and phospho-histone H3 staining. Treated animals showed a 10% absolute rise in ejection fraction and improved stroke volume, while vehicle controls declined. Histology confirmed localized cardiomyocyte division without detectable off-target proliferation at 28 days.
Sources (2)
- [1]Primary Source(https://www.nature.com/articles/s44161-024-00567-8)
- [2]Supporting Source(https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319876)